Retinal neovascular diseases including neovascular age-related macular degeneration (AMD), diabetic macular edema and retinal vein occlusion are the most vision-threatening diseases among the developed world working-age population. Around 200 million people worldwide, and 20 million adults in the U.S are thought to be living with AMD. The risk of getting advanced AMD increases from 2% for those ages 50-59, to nearly 30% for those over the age of 75.